We are developing methods to concurrently interrogate coding and non-coding gene expression or mutations, epigenetic information, and immunomic data, in order to inform basic and translational research, as well as clinical decision making.
Our “Whole Genome and Beyond” approach aims to maximize the layers of information that are extracted and exploited from a single patient sample. To this end, we are extensively employing bulk, single cell, and spatial transcriptomic technologies to characterize cellular transcriptional programs and cell-cell communication, as well as how they are derailed in disease. This approach permits us to identify and prioritize novel biomarkers or therapeutic targets, regardless of their coding potential.
The Non-Coding Research Lab is part of the Department of Pathology and the Cancer Research Institute at the Beth Israel Deaconess Medical Center, the Harvard Medical School, and the Broad Institute of MIT and Harvard.
It is also seamlessly integrated with the non-coding RNA core of the Harvard Initiative for RNA Medicine.
It is physically located at the Dana Building of the BIDMC East Campus.
